بررسی رابطه ائوزینوفیلی با درگیری عروق کرونر در بیماران مبتلا به بیماری کاوازاکی

Background and purpose: Kawasaki disease (KD) is an acute vasculitis in children. Studies indicated different relationships between eosinophilia and coronary artery disease (CAD). This study was done to assess the possible relationship between eosinophilia and coronary artery disease. Materials and methods: This descriptive study was carried out during 13 years on 61 children with Kawasaki disease who were admitted to Sina Referral Hospital. They were assessed regarding eosinophilia and coronary artery diseases. Data was evaluated by Fisher exact and t-test. Results: The research population included 61 patients of whom 33 (54%) were male and 28 (46%) were female with the mean age of 36.56 ± 23 months. Among the patients 85% were >5 years of age and eosinophilia was found in 28 cases (45.9%) and five patients (14.8%) were diagnosed with coronary artery disease. This disease was observed in 25% suffering from eosinophilia and in 6% of the cases without eosinophilia. However, there was no association among gender, eosinophilia and coronary artery disease. Also, no significant difference was found between age groups. Conclusion: Eosinophilia was not a risk factor or protective factor for CAD. However, the exact relationship could be determined if further multicentre studies are carried out.